26 October 2017
Andrew Dillin investigates the molecular pathways of aging. In particular, he focuses on how protein folding and conformations play a role in the aging process of cells and organisms and how diet can affect that link.
The goal of my research program is to understand and manipulate the molecular pathways that promote the healthy survival of an organism. Our hypothesis is that many of the signaling pathways that impinge on the aging process do so, in part, by directly modulating the molecular machinery that assists in protein folding and maintenance of their functional conformations, from both a static and dynamic perspective. My research group is divided into two related research clusters: one focuses on the identification of the molecular pathways of aging, and the second investigates how these pathways affect the fidelity of protein homeostasis, with an emphasis on diseases associated with protein misfolding. Our research cycles between initial discoveries in the worm Caenorhabditis elegans and more complex analyses in the mouse.